The driver's body was found overnight in the wreckage of the crash at Granges-près-Marnand in the canton of Vaud, police spokesman Jean-Christophe Sauterel said.
One of the injured was taken by helicopter to Lausanne. Others were treated on the spot by paramedics or taken to hospital by ambulance.
Police said 46 people were on the two trains, one of which was heading to Lausanne, the other was going to Payerne.
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